Disorders of sexual development - sex reversal(DSD)
Also known as: Disorders of Sex Development · XX Sex Reversal · Geschlechtsumkehr · SRY-negative XX DSD · Hermaphroditismus · …
Overview
What it is
This is a congenital condition affecting the reproductive system where a dog's genetic sex (their chromosomes) does not match their physical gonads (internal reproductive organs like ovaries or testes) or external genitalia. This mismatch occurs during early development in the womb. Because it is inherited in an autosomal recessive pattern, a puppy must inherit the mutated gene from both parents to be affected.
How it presents
Owners typically notice signs as the dog reaches puberty or young adulthood, usually around 6 to 12 months of age. Affected dogs are infertile, may fail to show normal heat cycles, and can have unusual or ambiguous-looking external genitalia that are prone to chronic irritation or infections.
Treatment
The condition is treatable, typically requiring a one-time surgical removal of the malformed reproductive organs to prevent future tumors and infections. This surgery is a one-time expense that generally costs between 600 and 1800 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
SRY-Gen-PCR-Test(SRY-PCR)
Primary testDNA testEin molekularbiologischer PCR-Test zum Nachweis des SRY-Gens in Kombination mit der Bestimmung des chromosomalen Geschlechts (XX), um eine SRY-negative XX-Geschlechtsentwicklungsstörung zu identifizieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Karyotypisierung (Chromosomenanalyse)(Karyotypisierung)
Primary testDNA testDie Karyotypisierung ist eine zytogenetische Untersuchung zur Bestimmung der Chromosomenanzahl und -struktur, mit der das Fehlen eines Geschlechtschromosoms (XO-Karyotyp) direkt nachgewiesen werden kann.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Karyotypisierung und SRY-Gen-PCR(SRY-PCR)
Primary testDNA testDer Test kombiniert die Bestimmung des Chromosomensatzes (Karyotypisierung zum Nachweis von XX) mit einer PCR-Untersuchung auf das SRY-Gen, um das Fehlen des Y-Chromosoms trotz männlicher Merkmale zu bestätigen.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Disorders of sexual development - sex reversal?
This is a congenital condition affecting the reproductive system where a dog's genetic sex (their chromosomes) does not match their physical gonads (internal reproductive organs like ovaries or testes) or external genitalia. This mismatch occurs during early development in the womb. Because it is inherited in an autosomal recessive pattern, a puppy must inherit the mutated gene from both parents to be affected.
How is Disorders of sexual development - sex reversal tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), SRY-Gen-PCR-Test, Karyotypisierung (Chromosomenanalyse), Karyotypisierung und SRY-Gen-PCR, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: American Staffordshire Terrier, Beagle, German Shorthaired Pointer, Miniature Pinscher, Norwegian Elkhound.