Stevens-Johnson syndrome, susceptibility to(SJS)
Also known as: Stevens-Johnson-Syndrom · Toxic Epidermal Necrolysis susceptibility · SJS/TEN · Arzneimittel-induzierte epidermale Nekrolyse
Overview
What it is
Stevens-Johnson syndrome is a severe, immune-mediated reaction affecting the skin and mucous membranes, where the body's immune system mistakenly attacks its own cells. This reaction is typically triggered by specific medications, such as phenobarbital, in dogs with a genetic predisposition. The condition causes the outer layer of the skin to die and separate from the deeper layers.
How it presents
Symptoms appear suddenly after exposure to a triggering drug and include painful blistering, open sores, and peeling skin, especially around the mouth, eyes, and genitals. Affected dogs also typically show severe lethargy and fever.
Treatment
This is a critical emergency requiring immediate, intensive hospital care and wound management. While it is a one-time reaction to a trigger rather than a lifelong disease, treatment is highly intensive and typically costs between 2,000 and 7,000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Stevens-Johnson syndrome, susceptibility to?
Stevens-Johnson syndrome is a severe, immune-mediated reaction affecting the skin and mucous membranes, where the body's immune system mistakenly attacks its own cells. This reaction is typically triggered by specific medications, such as phenobarbital, in dogs with a genetic predisposition. The condition causes the outer layer of the skin to die and separate from the deeper layers.
How is Stevens-Johnson syndrome, susceptibility to tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.