Spherocytosis(HS)
Overview
What it is
Hereditary spherocytosis is an inherited red blood cell disorder primarily documented in Golden Retrievers, caused by a deficiency in a structural protein called spectrin. This deficiency causes the red blood cells to become fragile and spherical instead of their normal disc shape, leading to their premature destruction. While this hereditary form is genetic, abnormally round red blood cells (spherocytes) are more commonly acquired as a feature of immune-mediated hemolytic anemia (IMHA).
How it presents
Affected dogs typically show symptoms from a young age. Owners may notice extreme lethargy, pale gums, yellowing of the skin or eyes, and dark urine after physical exertion.
Treatment
This lifelong condition is manageable rather than curable, requiring ongoing medical support and regular blood panels. In severe cases, blood transfusions may be necessary, with overall treatment costs ranging from 1,500 to 6,000 EUR.
How it's tested
Hereditäre Sphärozytose (HS) DNA-Test(HS)
Primary testDNA testEin Gentest identifiziert die ursächliche Mutation im SPTB-Gen, welche die Verformung und den vorzeitigen Abbau der roten Blutkörperchen verursacht.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Spherocytosis?
Hereditary spherocytosis is an inherited red blood cell disorder primarily documented in Golden Retrievers, caused by a deficiency in a structural protein called spectrin. This deficiency causes the red blood cells to become fragile and spherical instead of their normal disc shape, leading to their premature destruction. While this hereditary form is genetic, abnormally round red blood cells (spherocytes) are more commonly acquired as a feature of immune-mediated hemolytic anemia (IMHA).
How is Spherocytosis tested?
Tests currently in our database: Hereditäre Sphärozytose (HS) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.