High-activity sodium-potassium-ATPase
Also known as: High sodium-potassium ATPase activity · Erythrocyte sodium-potassium ATPase hyperactivity · Hereditary stomatocytosis of Alaskan Malamutes · Na-K-ATPase hyperactivity · Stomatocytosis with high Na-K ATPase
Overview
What it is
This genetic condition affects the red blood cells by causing overactivity in the sodium-potassium pump, which is the mechanism that regulates salt and water balance within the cells. This imbalance can cause the red blood cells to become misshapen into cup-like forms called stomatocytes, which can shorten their lifespan. It is typically identified through routine blood tests that show these abnormal cells and altered electrolyte levels.
How it presents
Most affected dogs show no outward signs of illness, and the condition is usually discovered incidentally during routine blood work in young adulthood. In rare cases, a dog might show mild lethargy or slightly reduced stamina due to mild anemia.
Treatment
No active treatment is typically required because the condition rarely impacts a dog's quality of life. Periodic veterinary monitoring and blood tests to check red blood cell counts may be recommended, costing between 150 and 800 EUR over the dog's lifetime.
How it's tested
Hämatologische Untersuchung und Blutausstrich(Blutbild & Elektrolyte)
Primary testClinical examDie Diagnose erfolgt klinisch durch den Nachweis von becherförmigen roten Blutkörperchen (Stomatozyten) im Blutausstrich sowie die Messung der Elektrolytkonzentrationen im Blut.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is High-activity sodium-potassium-ATPase?
This genetic condition affects the red blood cells by causing overactivity in the sodium-potassium pump, which is the mechanism that regulates salt and water balance within the cells. This imbalance can cause the red blood cells to become misshapen into cup-like forms called stomatocytes, which can shorten their lifespan. It is typically identified through routine blood tests that show these abnormal cells and altered electrolyte levels.
How is High-activity sodium-potassium-ATPase tested?
Tests currently in our database: Hämatologische Untersuchung und Blutausstrich.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.