S-locus(S)
Also known as: S Locus · Piebald locus · White spotting · MITF gene · Scheckungs-Lokus · …
Overview
What it is
The S-locus is a genetic region controlled by the MITF gene that regulates how pigment-producing cells distribute across a dog's skin and coat. When a dog inherits two copies of this recessive variant, it prevents pigment from developing in certain areas, resulting in white patches of fur and skin. This primarily affects the integumentary system (the skin and hair), but can occasionally impact the inner ear's pigment cells, which are vital for normal hearing.
How it presents
Owners will notice white patches on the coat from birth, which can range from minor markings to an almost entirely white coat. If the lack of pigment extends to the inner ear, congenital deafness may be present and noticeable from puppyhood.
Treatment
The coat variation itself requires no treatment, but dogs with extensive white skin may need lifelong sun protection, and deaf dogs require specialized training, with typical management costs ranging from 0 to 500 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
S-Lokus (White Spotting) DNA-Test(S-Lokus)
Primary testDNA testDer DNA-Test untersucht das MITF-Gen auf das Vorhandensein des Scheckungs-Allels (s), welches für weiße Fellzeichnungen verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is S-locus?
The S-locus is a genetic region controlled by the MITF gene that regulates how pigment-producing cells distribute across a dog's skin and coat. When a dog inherits two copies of this recessive variant, it prevents pigment from developing in certain areas, resulting in white patches of fur and skin. This primarily affects the integumentary system (the skin and hair), but can occasionally impact the inner ear's pigment cells, which are vital for normal hearing.
How is S-locus tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), S-Lokus (White Spotting) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Eurasier.