Robinow-like syndrome (DVL2)(DVL2)
Also known as: Robinow-like syndrome · DVL2 mutation · DVL2-associated Robinow-like syndrome · Screw tail mutation
Overview
What it is
Robinow-like syndrome is an inherited developmental disorder that affects the skeletal system, specifically the spine, skull, and tail, due to a mutation in the DVL2 gene. This genetic mutation disrupts normal bone and cartilage development, leading to structural malformations such as a tightly coiled tail and abnormally shaped spinal bones called hemivertebrae. These spinal abnormalities can put pressure on the spinal cord, potentially damaging the nervous system.
How it presents
Owners will typically notice physical signs starting in puppyhood, such as a severely kinked tail, a shortened muzzle, or an abnormal gait. As the dog grows, spinal compression can lead to more severe neurological symptoms, including back pain, weakness in the hind legs, or incontinence.
Treatment
While the underlying genetic defect cannot be cured, symptoms can be managed with lifelong pain relief, physical therapy, or corrective spinal surgery in severe cases. Depending on whether conservative management or complex surgery is required, treatment costs typically range from 1,500 to 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Robinow-like syndrome (DVL2)?
Robinow-like syndrome is an inherited developmental disorder that affects the skeletal system, specifically the spine, skull, and tail, due to a mutation in the DVL2 gene. This genetic mutation disrupts normal bone and cartilage development, leading to structural malformations such as a tightly coiled tail and abnormally shaped spinal bones called hemivertebrae. These spinal abnormalities can put pressure on the spinal cord, potentially damaging the nervous system.
How is Robinow-like syndrome (DVL2) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Continental Bulldog.