SLC7A10-related paradoxical pseudomyotonia(PPM)
Also known as: Paradoxical pseudomyotonia · PP
Overview
What it is
This is a hereditary muscle disorder affecting the skeletal muscles, where the muscles fail to relax normally after contraction or when exposed to cold temperatures. It is caused by a genetic mutation in the SLC7A10 gene, which disrupts the chemical signals needed for muscles to loosen up after tensing.
How it presents
Symptoms typically appear in puppies or young dogs as sudden muscle stiffness or a temporary inability to move following physical activity or cold exposure. These episodes generally subside after a short rest.
Treatment
The condition is not curable but can be managed long-term with lifestyle adjustments and medication. Lifelong supportive care is estimated to cost between 1,000 and 4,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is SLC7A10-related paradoxical pseudomyotonia?
This is a hereditary muscle disorder affecting the skeletal muscles, where the muscles fail to relax normally after contraction or when exposed to cold temperatures. It is caused by a genetic mutation in the SLC7A10 gene, which disrupts the chemical signals needed for muscles to loosen up after tensing.
How is SLC7A10-related paradoxical pseudomyotonia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.