Prekallikrein deficiency
Also known as: Fletcher factor deficiency · Prekallikrein-Mangel · Fletcher-Faktor-Mangel · Congenital prekallikrein deficiency · Präkallikrein-Mangel · …
Overview
What it is
Prekallikrein deficiency is an inherited blood disorder where the body lacks a specific protein needed for the normal clotting process. This protein, called prekallikrein, helps activate the chemical reactions that stop bleeding. Despite its role in the circulatory system, this deficiency does not impair the dog's actual ability to form clots in real-world scenarios.
How it presents
Affected dogs typically show no physical symptoms at all, and the condition is present from birth. It is usually discovered by chance during routine pre-surgery blood tests that show an abnormally long clotting time.
Treatment
No treatment is necessary because the condition does not cause health problems or affect life expectancy. The only associated costs are one-time diagnostic blood tests, which typically range from 50 to 250 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
PKD1 DNA-Test(PKD)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im PKD1-Gen, welche für die Entstehung von Zystennieren verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Prekallikrein deficiency?
Prekallikrein deficiency is an inherited blood disorder where the body lacks a specific protein needed for the normal clotting process. This protein, called prekallikrein, helps activate the chemical reactions that stop bleeding. Despite its role in the circulatory system, this deficiency does not impair the dog's actual ability to form clots in real-world scenarios.
How is Prekallikrein deficiency tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), PKD1 DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.