Polysaccharide Storage Myopathy (PSSM1)(PSSM1)
Also known as: Polysaccharid-Speicher-Myopathie · Exertional Rhabdomyolysis · Belastungsinduzierte Myopathie · Tying-up Syndrom beim Hund · Glykogenspeicherkrankheit der Muskeln · …
Overview
What it is
This is a genetic metabolic disorder affecting the muscles, where the dog's body abnormally stores excess sugar, called glycogen, inside muscle cells. Because the muscles cannot process this stored sugar properly, they suffer from an energy deficit and damage during physical activity. This damage to the muscle fibers is known as exertional rhabdomyolysis.
How it presents
Owners will typically notice symptoms after exercise, including muscle stiffness, trembling, painful cramps, and a reluctance to move. In severe cases, the breakdown of muscle tissue can cause the dog's urine to appear dark. These signs usually first emerge in young to middle-aged adult dogs.
Treatment
The condition is not curable but can be managed long-term with a specialized low-carbohydrate, high-fat diet and carefully regulated exercise. Lifelong management, including veterinary check-ups and dietary adjustments, typically costs between 1,500 and 6,000 EUR.
How it's tested
Muskelbiopsie und Histopathologie(Muskelbiopsie)
Primary testClinical examDie Diagnose der Polymyositis wird durch eine Muskelbiopsie gesichert, bei der entzündliche Infiltrate und Muskelfasernekrosen histopathologisch nachgewiesen werden.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polysaccharide Storage Myopathy (PSSM1)?
This is a genetic metabolic disorder affecting the muscles, where the dog's body abnormally stores excess sugar, called glycogen, inside muscle cells. Because the muscles cannot process this stored sugar properly, they suffer from an energy deficit and damage during physical activity. This damage to the muscle fibers is known as exertional rhabdomyolysis.
How is Polysaccharide Storage Myopathy (PSSM1) tested?
Tests currently in our database: Muskelbiopsie und Histopathologie.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.