Polyneuropathy, SBF2-related(MSP)
Also known as: SBF2-related Polyneuropathy · Miniature Schnauzer Polyneuropathy · Demyelinating Polyneuropathy · Charcot-Marie-Tooth Disease Type 4B2 Homolog
Overview
What it is
SBF2-associated polyneuropathy is an inherited disease of the peripheral nervous system, which consists of the nerves outside the brain and spinal cord. It damages the myelin sheath, the protective outer coating of nerve fibers that is essential for transmitting signals. Without this healthy coating, communication between the brain and the muscles progressively breaks down.
How it presents
Symptoms usually appear within the first year of life, starting with coordination issues or weakness in the back legs. Owners may also notice breathing difficulties, changes in their dog's bark, or hoarseness due to paralysis of the vocal cords.
Treatment
There is no cure for this progressive condition, and management focuses on supportive care and physical therapy to maintain mobility. Lifelong supportive care typically costs between €1,500 and €6,000.
How it's tested
SBF2-Polyneuropathie DNA-Test(SBF2-PN)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im SBF2-Gen, um betroffene Hunde sowie symptomfreie Träger der autosomal-rezessiven Polyneuropathie sicher zu bestimmen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, SBF2-related?
SBF2-associated polyneuropathy is an inherited disease of the peripheral nervous system, which consists of the nerves outside the brain and spinal cord. It damages the myelin sheath, the protective outer coating of nerve fibers that is essential for transmitting signals. Without this healthy coating, communication between the brain and the muscles progressively breaks down.
How is Polyneuropathy, SBF2-related tested?
Tests currently in our database: SBF2-Polyneuropathie DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.