Polyneuropathy, RAB3GAP1-related(JLPP)
Also known as: Juvenile Laryngeal Paralysis and Polyneuropathy · RAB3GAP1-associated polyneuropathy · Polyneuropathy in Black Russian Terriers · RAB3GAP1-related JLPP · Kehlkopflähmung und Polyneuropathie · …
Overview
What it is
This is a severe, inherited neurological disease affecting the peripheral nervous system, which controls movement and breathing. It is caused by a genetic mutation in the RAB3GAP1 gene that disrupts normal nerve function and communication. Over time, this disruption leads to progressive damage to the nerves throughout the body.
How it presents
Symptoms typically begin between 3 and 6 months of age, starting with hoarseness, swallowing difficulties, and breathing problems caused by paralysis of the voice box. As the disease progresses, owners will notice worsening muscle weakness and paralysis in the limbs.
Treatment
There is no cure for this progressive condition, and treatment is limited to supportive care to keep the dog comfortable. Because of the severity of the symptoms, euthanasia is often necessary within the first year of life, with palliative care and diagnostic costs typically ranging from 500 to 2,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, RAB3GAP1-related?
This is a severe, inherited neurological disease affecting the peripheral nervous system, which controls movement and breathing. It is caused by a genetic mutation in the RAB3GAP1 gene that disrupts normal nerve function and communication. Over time, this disruption leads to progressive damage to the nerves throughout the body.
How is Polyneuropathy, RAB3GAP1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: American Staffordshire Terrier.