Polyneuropathy 1 (Leonberger, Saint Bernard)(LPN1)
Also known as: Leonberger Polyneuropathy Type 1 · LPN1-Polyneuropathie · Inherited Polyneuropathy 1 · Leonberger Polyneuropathy 1 · Polyneuropathie beim Leonberger Typ 1
Overview
What it is
Leonberger Polyneuropathy 1 (LPN1) is an inherited neurological disorder that causes progressive damage to the peripheral nerves, which are the nerves connecting the brain and spinal cord to the rest of the body. This damage disrupts the electrical signals traveling between the brain and the muscles, leading to muscle weakness and coordination issues.
How it presents
Symptoms typically appear between 1 and 3 years of age, starting with an unsteady gait, stumbling, and weakness in the hind legs. Affected dogs may also develop harsh breathing sounds or difficulty breathing due to paralysis of the vocal cords.
Treatment
There is no cure for this progressive condition, meaning treatment is limited to lifelong supportive care and physical therapy to maintain mobility. Managing this disease typically costs between €1,500 and €5,000 over the dog's lifetime.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy 1 (Leonberger, Saint Bernard)?
Leonberger Polyneuropathy 1 (LPN1) is an inherited neurological disorder that causes progressive damage to the peripheral nerves, which are the nerves connecting the brain and spinal cord to the rest of the body. This damage disrupts the electrical signals traveling between the brain and the muscles, leading to muscle weakness and coordination issues.
How is Polyneuropathy 1 (Leonberger, Saint Bernard) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Leonberger.