Polyglandular autoimmune syndrome, type II(PGA II)
Also known as: Polyglanduläres Autoimmunsyndrom Typ II · Schmidt-Syndrom · Polyglandular Autoimmune Syndrome Type 2 · PAS Type II · Polyglandular Endocrinopathy Type II · …
Overview
What it is
Polyglandular Autoimmune Syndrome Type II, also known as APS 2 or Schmidt's syndrome, is a severe metabolic and endocrine disorder where the immune system mistakenly attacks multiple hormone-producing glands. This typically targets organs like the adrenal glands, thyroid, and pancreas, which control vital metabolic processes. Because these glands are destroyed, the body can no longer produce the essential hormones needed to regulate daily functions.
How it presents
Symptoms usually appear in young to middle-aged dogs and include extreme weakness, vomiting, weight loss, and increased thirst. Without intervention, these signs can escalate into a sudden, life-threatening hormonal crisis.
Treatment
This condition is incurable and requires lifelong, carefully managed hormone replacement therapy and regular blood monitoring. Lifetime treatment and management costs typically range from 4,000 to 15,000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyglandular autoimmune syndrome, type II?
Polyglandular Autoimmune Syndrome Type II, also known as APS 2 or Schmidt's syndrome, is a severe metabolic and endocrine disorder where the immune system mistakenly attacks multiple hormone-producing glands. This typically targets organs like the adrenal glands, thyroid, and pancreas, which control vital metabolic processes. Because these glands are destroyed, the body can no longer produce the essential hormones needed to regulate daily functions.
How is Polyglandular autoimmune syndrome, type II tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.