Platelet dysfunction (thrombocytopathia, Basset hound thrombopathia)(BHT)
Also known as: Basset Hound Thrombopathia · Thrombocytopathia · Thrombopathia in Basset Hounds · Platelet Dysfunction Basset Hound Type · Basset Hound Thrombopathy · …
Overview
What it is
This is an inherited blood clotting disorder caused by a genetic mutation in the RASGRP2 gene, which affects how platelets (the blood cells responsible for stopping bleeding) function. Even though the dog has a normal number of platelets, these cells cannot clump together properly to form clots. This impairs the circulatory system's ability to heal wounds and control bleeding.
How it presents
Symptoms typically appear at a young age and include frequent nosebleeds, bleeding gums, unexplained bruising, or prolonged bleeding after minor injuries. Owners may also notice excessive bleeding during teething or after routine veterinary procedures.
Treatment
There is no cure, but the condition can be managed daily by avoiding injury and certain medications like aspirin. In the event of surgery or trauma, supportive treatments like blood or platelet transfusions are required, with lifetime management costs typically ranging from €500 to €4,500.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Basset Hound Thrombopathie (BHT) DNA-Test(BHT)
Primary testDNA testEin DNA-Test zum Nachweis der Mutation im RASGRP1-Gen, die für die Basset Hound Thrombopathie verantwortlich ist und zu Funktionsstörungen der Blutplättchen führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Platelet dysfunction (thrombocytopathia, Basset hound thrombopathia)?
This is an inherited blood clotting disorder caused by a genetic mutation in the RASGRP2 gene, which affects how platelets (the blood cells responsible for stopping bleeding) function. Even though the dog has a normal number of platelets, these cells cannot clump together properly to form clots. This impairs the circulatory system's ability to heal wounds and control bleeding.
How is Platelet dysfunction (thrombocytopathia, Basset hound thrombopathia) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Basset Hound Thrombopathie (BHT) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Basset Artésien Normand, Basset Hound, Great Pyrenees, Boxer, Finnish Spitz, German Shepherd.