Plasminogen activator inhibitor-1 deficiency, SERPINE1-related(PAI-1)
Also known as: PAI-1 deficiency · Plasminogenaktivator-Inhibitor-1-Mangel · SERPINE1 deficiency · SERPINE1-related bleeding disorder · Hyperfibrinolysis due to PAI-1 deficiency
Overview
What it is
This is an inherited bleeding disorder affecting the blood circulatory system, specifically how the body stabilizes blood clots. It is caused by a deficiency in a protein called plasminogen activator inhibitor-1 (PAI-1), which normally stops clots from dissolving too quickly. Without enough PAI-1, the body breaks down blood clots prematurely, leading to impaired clotting.
How it presents
Affected dogs usually show no symptoms in their daily lives and appear completely healthy. However, they will experience severe, delayed, and prolonged bleeding hours or days after undergoing a surgery, dental work, or sustaining an injury, which can first be noticed at any age when their first procedure occurs.
Treatment
The condition is not curable, but it can be managed successfully using specific clot-stabilizing medications before and after scheduled surgeries. Treatment is only needed on an as-needed basis around medical procedures rather than as a lifelong daily therapy, with costs ranging from 500 to 3000 EUR.
How it's tested
Plasminogen-Aktivator-Inhibitor-1-Defizienz Gentest(PAI-1)
Primary testDNA testEin Gentest identifiziert die ursächliche Mutation im SERPINE1-Gen, welche zu einem Mangel an Plasminogen-Aktivator-Inhibitor-1 und damit zu einer gestörten Blutgerinnung führt.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Plasminogen activator inhibitor-1 deficiency, SERPINE1-related?
This is an inherited bleeding disorder affecting the blood circulatory system, specifically how the body stabilizes blood clots. It is caused by a deficiency in a protein called plasminogen activator inhibitor-1 (PAI-1), which normally stops clots from dissolving too quickly. Without enough PAI-1, the body breaks down blood clots prematurely, leading to impaired clotting.
How is Plasminogen activator inhibitor-1 deficiency, SERPINE1-related tested?
Tests currently in our database: Plasminogen-Aktivator-Inhibitor-1-Defizienz Gentest.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.