Pelger-Huet anomaly(PHA)
Also known as: Pelger-Huët-Anomalie · Pelger-Huet-Anomalie · Pelger's anomaly · Congenital hyposegmentation of granulocytes · Pelger-Huet-Anomalie der Leukozyten · …
Overview
What it is
The Pelger-Huet anomaly is a harmless, inherited variation affecting the white blood cells, specifically a type of immune cell called granulocytes. In affected dogs, the nuclei of these cells do not segment or mature into their typical multi-lobed shape, though they continue to function completely normally. This condition is usually discovered by chance during routine blood tests and does not harm the dog's immune system.
How it presents
Dogs with one copy of the gene show no symptoms, are entirely healthy, and have a normal lifespan from birth. However, puppies that inherit the gene from both parents typically die before or shortly after birth due to severe skeletal defects.
Treatment
No treatment is necessary for affected dogs because this variation is harmless and does not affect their health. There are no associated medical costs, resulting in a lifetime treatment cost of 0 EUR.
How it's tested
Pelger-Huët-Anomalie (PHA) DNA-Test(PHA)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im LBR-Gen für die Pelger-Huët-Anomalie, um betroffene Hunde und Anlageträger sicher zu bestimmen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Pelger-Huet anomaly?
The Pelger-Huet anomaly is a harmless, inherited variation affecting the white blood cells, specifically a type of immune cell called granulocytes. In affected dogs, the nuclei of these cells do not segment or mature into their typical multi-lobed shape, though they continue to function completely normally. This condition is usually discovered by chance during routine blood tests and does not harm the dog's immune system.
How is Pelger-Huet anomaly tested?
Tests currently in our database: Pelger-Huët-Anomalie (PHA) DNA-Test.
Which breeds are most affected?
Most commonly affected: American Foxhound.