Palmoplantar keratoderma, nonepidermolytic, focal 1(HFH)
Also known as: Hereditary Footpad Hyperkeratosis · Focal Non-Epidermolytic Palmoplantar Keratoderma · Pfotenhyperkeratose · KRT16-related Hyperkeratosis · Digit Hyperkeratosis · …
Overview
What it is
This is a hereditary skin disorder that affects the paw pads, caused by a genetic mutation that disrupts how keratin, a protective protein in the skin, is produced. This disruption leads to an abnormal, extreme thickening of the outer layer of the paw pads. It is specifically known to affect the Dogue de Bordeaux breed.
How it presents
Owners will typically notice cracked, hardened, and thickened paw pads starting within the first few months of a puppy's life. This can cause discomfort or pain when walking, leading to lameness, and the cracked skin can sometimes develop secondary infections.
Treatment
While there is no cure, the condition can be managed with lifelong daily care, including regular trimming of the excess hard tissue and applying moisturizing ointments. Managing this condition over a dog's lifetime typically costs between 1,000 and 4,000 EUR.
How it's tested
Hereditäre Fußballenhyperkeratose (HFH) DNA-Test(HFH)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im FAM83G-Gen, die zur Verhornung der Fußballen führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Palmoplantar keratoderma, nonepidermolytic, focal 1?
This is a hereditary skin disorder that affects the paw pads, caused by a genetic mutation that disrupts how keratin, a protective protein in the skin, is produced. This disruption leads to an abnormal, extreme thickening of the outer layer of the paw pads. It is specifically known to affect the Dogue de Bordeaux breed.
How is Palmoplantar keratoderma, nonepidermolytic, focal 1 tested?
Tests currently in our database: Hereditäre Fußballenhyperkeratose (HFH) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.