Nodular dermatofibrosis and renal cystadenocarcinoma(RCND)
Also known as: Hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis · Noduläre Dermatofibrose des Schäferhundes · Renal cystadenocarcinoma and nodular dermatofibrosis · RCND syndrome · Nierenzellkarzinom und noduläre Dermatofibrose · …
Overview
What it is
This is an inherited condition that affects both the skin and the kidneys. It causes non-cancerous, firm lumps of connective tissue (nodules) to form under the skin, while simultaneously causing fluid-filled sacs (cysts) and cancerous tumors to grow in the kidneys. Over time, these kidney abnormalities damage the organ's ability to filter waste from the blood.
How it presents
Owners usually first notice firm, painless skin bumps on the dog's legs or head, typically appearing between 3 and 6 years of age. As the kidney damage progresses, the dog may show signs of kidney failure, such as drinking and urinating much more than usual, vomiting, and losing weight.
Treatment
There is no cure for this condition, and treatment is lifelong and supportive to manage kidney failure and maintain quality of life. Supportive veterinary care and monitoring typically cost between 1,500 and 5,000 EUR.
How it's tested
RCND DNA-Test(RCND)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im FLCN-Gen, die zu Nierenzystenadenokarzinomen und nodulärer Dermatofibrose führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Nodular dermatofibrosis and renal cystadenocarcinoma?
This is an inherited condition that affects both the skin and the kidneys. It causes non-cancerous, firm lumps of connective tissue (nodules) to form under the skin, while simultaneously causing fluid-filled sacs (cysts) and cancerous tumors to grow in the kidneys. Over time, these kidney abnormalities damage the organ's ability to filter waste from the blood.
How is Nodular dermatofibrosis and renal cystadenocarcinoma tested?
Tests currently in our database: RCND DNA-Test.
Which breeds are most affected?
Most commonly affected: German Shepherd.