Hypertrophic neuropathy(HN)
Also known as: Congenital hypertrophic neuropathy · Hypertrophe Neuropathie · Demyelinating polyneuropathy · Canine Inherited Demyelinative Neuropathy · CIDN
Overview
What it is
Hypertrophic neuropathy, also known as Canine Inherited Demyelinative Neuropathy (CIDN), is an inherited disorder of the peripheral nervous system. In affected dogs, the protective myelin sheath surrounding the nerves abnormally thickens, which disrupts the electrical signals traveling between the brain and the muscles. This disruption leads to progressive weakness and muscle wasting.
How it presents
Symptoms typically appear in puppies between 7 and 10 weeks of age. Owners will first notice an unsteady, wobbly gait and weakness in the hind legs, which quickly progresses to severe muscle loss and an inability to stand.
Treatment
There is no cure for this progressive condition, and veterinary care is focused on diagnostics and supportive care, typically costing between 500 and 2000 EUR. Because the disease is severe and rapidly worsens, humane euthanasia is often recommended to prevent suffering.
How it's tested
Hypertrophic Neuropathy (HN) DNA-Test(HN)
Primary testDNA testEin DNA-Test identifiziert die ursächliche genetische Mutation für die hypertrophische Neuropathie, was eine frühzeitige Diagnose und die Identifikation von Anlageträgern ermöglicht.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hypertrophic neuropathy?
Hypertrophic neuropathy, also known as Canine Inherited Demyelinative Neuropathy (CIDN), is an inherited disorder of the peripheral nervous system. In affected dogs, the protective myelin sheath surrounding the nerves abnormally thickens, which disrupts the electrical signals traveling between the brain and the muscles. This disruption leads to progressive weakness and muscle wasting.
How is Hypertrophic neuropathy tested?
Tests currently in our database: Hypertrophic Neuropathy (HN) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.