Neuronal Ceroid Lipofuscinosis 8 (Saluki)(NCL-8)
Also known as: Neuronal Ceroid Lipofuscinosis Type 8 · NCL CLN8 · Saluki NCL · Neuronale Zeroidlipofuszinose Typ 8 · Ceroid-Lipofuszinose Saluki
Overview
What it is
Neuronal Ceroid Lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder that affects the dog's nervous system. It is caused by a genetic mutation that prevents cells from breaking down waste products, leading to a harmful buildup of fatty pigments inside nerve cells. Over time, this accumulation damages and destroys vital brain tissue.
How it presents
Symptoms typically begin to appear between one and two years of age, starting with vision loss, behavioral changes, and an unsteady gait. These signs worsen rapidly and often progress to severe coordination problems and seizures.
Treatment
There is no cure for this disease, and treatment is limited to supportive care to keep the dog comfortable. Managing these symptoms over the dog's remaining life typically costs between 1,000 and 3,000 EUR, and humane euthanasia is eventually recommended to prevent suffering.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal Ceroid Lipofuscinosis 8 (Saluki)?
Neuronal Ceroid Lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder that affects the dog's nervous system. It is caused by a genetic mutation that prevents cells from breaking down waste products, leading to a harmful buildup of fatty pigments inside nerve cells. Over time, this accumulation damages and destroys vital brain tissue.
How is Neuronal Ceroid Lipofuscinosis 8 (Saluki) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.