Neuronal Ceroid Lipofuscinosis 10 (American Bulldog)(NCL-10)
Also known as: NCL-CTSD · Neuronale Zeroidlipofuszinose Typ 10 · NCL 10 · NCL Type 10 · Ceroid-Lipofuszinose Typ 10
Overview
What it is
Neuronal Ceroid Lipofuscinosis Type 10 (NCL-10) is an inherited metabolic disorder that affects the central nervous system. Due to a genetic mutation, the dog's body lacks a vital enzyme needed to clear cellular waste, leading to a harmful buildup of fat-protein deposits inside the brain's nerve cells. Over time, this accumulation damages and destroys these cells, causing progressive neurological decline.
How it presents
Owners typically notice symptoms starting between 9 and 12 months of age, including uncoordinated movement, tremors, behavioral changes, and progressive vision loss. These signs tend to worsen rapidly as the disease progresses.
Treatment
There is no cure for this fatal condition, and treatment is limited to supportive care to keep the dog comfortable. Managing symptoms and providing palliative care typically costs between 1,000 and 3,500 EUR before euthanasia becomes necessary.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
NCL10 DNA-Test(NCL10)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im CTSD-Gen, die zur neuronalen Ceroid-Lipofuszinose Typ 10 führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal Ceroid Lipofuscinosis 10 (American Bulldog)?
Neuronal Ceroid Lipofuscinosis Type 10 (NCL-10) is an inherited metabolic disorder that affects the central nervous system. Due to a genetic mutation, the dog's body lacks a vital enzyme needed to clear cellular waste, leading to a harmful buildup of fat-protein deposits inside the brain's nerve cells. Over time, this accumulation damages and destroys these cells, causing progressive neurological decline.
How is Neuronal Ceroid Lipofuscinosis 10 (American Bulldog) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), NCL10 DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.