Neuronal ceroid lipofuscinosis, 6(NCL6)
Also known as: Neuronal Ceroid Lipofuscinosis Type 6 · CLN6 · Ceroid-Lipofuszinose Typ 6 · NCL 6 · Neuronal ceroid-lipofuscinosis 6
Overview
What it is
Neuronal ceroid lipofuscinosis type 6 (NCL6) is an inherited metabolic disorder that affects the nervous system. It occurs when the body fails to properly break down cellular waste, causing fatty pigments called lipofuscins to build up inside nerve cells. This accumulation gradually damages and destroys cells in the brain and other tissues.
How it presents
Owners typically notice symptoms starting between 1.5 and 2 years of age. These signs include progressive vision loss, disorientation, difficulty coordinating movements, and epileptic seizures.
Treatment
There is no cure for this condition, and treatment is limited to supportive care to manage symptoms like seizures. This lifelong palliative management typically costs between 1,000 and 3,000 EUR.
How it's tested
NCL6 DNA-Test(NCL6)
Primary testDNA testEin Gentest, der die spezifische Mutation im CLN6-Gen nachweist, um betroffene Hunde, Träger und mutationsfreie Tiere zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal ceroid lipofuscinosis, 6?
Neuronal ceroid lipofuscinosis type 6 (NCL6) is an inherited metabolic disorder that affects the nervous system. It occurs when the body fails to properly break down cellular waste, causing fatty pigments called lipofuscins to build up inside nerve cells. This accumulation gradually damages and destroys cells in the brain and other tissues.
How is Neuronal ceroid lipofuscinosis, 6 tested?
Tests currently in our database: NCL6 DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.