Neuronal ceroid lipofuscinosis, type 5(NCL5)
Also known as: Neuronal Ceroid Lipofuscinosis 5 · CLN5 · Neuronal Ceroid Lipofuscinosis Border Collie Type · Ceroid-Lipofuszinose Typ 5 · NCL - Border Collie
Overview
What it is
Neuronal ceroid lipofuscinosis type 5 (NCL 5) is an inherited disorder that affects the dog's nervous system. It is classified as a lysosomal storage disease, which means the cells' natural recycling centers fail to break down waste products properly. This leads to a harmful buildup of fatty pigments in the brain cells, causing them to gradually break down and die.
How it presents
Affected dogs usually start showing symptoms between one and two years of age. Owners typically notice behavioral changes such as aggression or confusion, alongside a loss of coordination and progressive blindness.
Treatment
There is no cure for this progressive disease, so treatment focuses entirely on supportive care to maintain comfort. Palliative care and symptom management over the dog's remaining life typically cost between 1,000 and 3,500 EUR.
How it's tested
NCL 5 DNA-Test(NCL5)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im CLN5-Gen, die für die neuronale Ceroid-Lipofuszinose Typ 5 verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal ceroid lipofuscinosis, type 5?
Neuronal ceroid lipofuscinosis type 5 (NCL 5) is an inherited disorder that affects the dog's nervous system. It is classified as a lysosomal storage disease, which means the cells' natural recycling centers fail to break down waste products properly. This leads to a harmful buildup of fatty pigments in the brain cells, causing them to gradually break down and die.
How is Neuronal ceroid lipofuscinosis, type 5 tested?
Tests currently in our database: NCL 5 DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.