Neuroaxonal dystrophy, VPS11-related(NAD)
Also known as: VPS11-related NAD · Neuroaxonal Dystrophy Rottweiler Type · VPS11 neuroaxonal dystrophy · Rottweiler NAD · Neuroaxonale Dystrophie
Overview
What it is
This is an inherited neurological disorder affecting the brain and spinal cord, caused by a genetic mutation in the VPS11 gene. The mutation leads to progressive damage and swelling of nerve fibers, known as axons, which are the pathways that transmit signals throughout the nervous system. As these fibers deteriorate, the brain loses its ability to communicate properly with the rest of the body.
How it presents
Symptoms typically appear between a few months and two years of age, beginning with mild coordination issues. Owners will notice worsening movement disorders, tremors, a head tilt, and an increasingly unsteady gait.
Treatment
There is no cure for this progressive disease, and veterinary care is focused entirely on keeping the dog comfortable. Supportive care and eventual humane euthanasia typically cost between 500 and 1,500 EUR.
How it's tested
VPS11-assoziierte Neuroaxonale Dystrophie (NAD) DNA-Test(NAD (VPS11))
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im VPS11-Gen, die für die neuroaxonale Dystrophie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuroaxonal dystrophy, VPS11-related?
This is an inherited neurological disorder affecting the brain and spinal cord, caused by a genetic mutation in the VPS11 gene. The mutation leads to progressive damage and swelling of nerve fibers, known as axons, which are the pathways that transmit signals throughout the nervous system. As these fibers deteriorate, the brain loses its ability to communicate properly with the rest of the body.
How is Neuroaxonal dystrophy, VPS11-related tested?
Tests currently in our database: VPS11-assoziierte Neuroaxonale Dystrophie (NAD) DNA-Test.
Which breeds are most affected?
Most commonly affected: Spanish Water Dog, Phalene, Continental Toy Spaniel.