Neuroaxonal dystrophy, TECPR2-related(NAD)
Also known as: TECPR2-NAD · Neuroaxonal Dystrophy Spanish Water Dog · Neuroaxonale Dystrophie Spanischer Wasserhund · TECPR2-associated neuroaxonal dystrophy · Neuroaxonal Dystrophy · …
Overview
What it is
This is a severe, inherited nervous system disorder caused by a genetic mutation in the TECPR2 gene. It leads to neuroaxonal dystrophy, a condition where the nerve fibers, or axons, in the brain and spinal cord swell and progressively degenerate. Because these damaged nerve cells cannot properly transmit signals, the dog's neurological function steadily declines.
How it presents
Symptoms typically appear between 6 and 12 months of age, starting with a loss of coordination, tremors, and abnormal movement patterns. These issues worsen rapidly, often accompanied by noticeable behavioral changes.
Treatment
There is no cure for this progressive disease, so treatment is limited to supportive care to keep the dog comfortable. Managing these symptoms throughout the dog's life typically costs between 500 and 2,500 EUR before humane euthanasia becomes necessary.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuroaxonal dystrophy, TECPR2-related?
This is a severe, inherited nervous system disorder caused by a genetic mutation in the TECPR2 gene. It leads to neuroaxonal dystrophy, a condition where the nerve fibers, or axons, in the brain and spinal cord swell and progressively degenerate. Because these damaged nerve cells cannot properly transmit signals, the dog's neurological function steadily declines.
How is Neuroaxonal dystrophy, TECPR2-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.