Neuroaxonal dystrophy, RNF170-related(NAD)
Also known as: Neuroaxonal Dystrophy · RNF170-NAD · Neuroaxonale Dystrophie · RNF170-related NAD · Canine Neuroaxonal Dystrophy
Overview
What it is
This is a severe inherited disorder of the nervous system caused by a genetic mutation. It leads to abnormal swellings along the nerve fibers, which disrupt the transmission of signals between the brain and the rest of the body.
How it presents
Symptoms typically appear between a few months and one year of age, starting with uncoordinated movement, tremors, and temperament changes. These signs progress rapidly as the dog loses control over its limbs.
Treatment
There is no cure for this condition, and care is limited to supportive, palliative measures to keep the dog comfortable. Managing the disease until euthanasia is necessary typically costs between 500 and 2,500 EUR.
How it's tested
RNF170-assoziierte Neuroaxonale Dystrophie (NAD) DNA-Test(NAD (RNF170))
Primary testDNA testDieser DNA-Test identifiziert die ursächliche Mutation im RNF170-Gen, um betroffene Hunde, Träger und mutationsfreie Tiere zu bestimmen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuroaxonal dystrophy, RNF170-related?
This is a severe inherited disorder of the nervous system caused by a genetic mutation. It leads to abnormal swellings along the nerve fibers, which disrupt the transmission of signals between the brain and the rest of the body.
How is Neuroaxonal dystrophy, RNF170-related tested?
Tests currently in our database: RNF170-assoziierte Neuroaxonale Dystrophie (NAD) DNA-Test.
Which breeds are most affected?
Most commonly affected: Bullmastiff.