Neuroaxonal dystrophy(NAD)
Also known as: Neuroaxonale Dystrophie · Canine Neuroaxonal Dystrophy · Neuroaxonal Degeneration · Infantile Neuroaxonal Dystrophy · Neuroaxonale Degeneration · …
Overview
What it is
Neuroaxonal dystrophy is a severe, inherited disorder of the central nervous system where the endings of nerve cells, called axons, swell and degenerate. Axons act like electrical wires that transmit signals between the brain and the body, and their breakdown disrupts normal communication. This progressive deterioration leads to widespread neurological dysfunction.
How it presents
Symptoms typically appear within the first year of a dog's life, starting with a stiff, uncoordinated walk and balance issues. Over time, these signs worsen to include head tremors and a general loss of body control.
Treatment
There is no cure for this progressive condition, and management is limited to supportive care or eventual euthanasia. Diagnostic testing, such as an MRI, and palliative care typically cost between €1,000 and €3,500.
How it's tested
Hüftgelenksdysplasie-Auswertung (HD-Röntgen) nach FCI(HD-FCI)
Primary testRadiographRöntgenaufnahme der Hüftgelenke unter Sedation, ausgewertet nach FCI-Standard (A-E). Standardpflicht bei den meisten VDH-Zuchtvereinen.
Issuing body: FCI
Result scheme: HD-FCI
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuroaxonal dystrophy?
Neuroaxonal dystrophy is a severe, inherited disorder of the central nervous system where the endings of nerve cells, called axons, swell and degenerate. Axons act like electrical wires that transmit signals between the brain and the body, and their breakdown disrupts normal communication. This progressive deterioration leads to widespread neurological dysfunction.
How is Neuroaxonal dystrophy tested?
Tests currently in our database: Hüftgelenksdysplasie-Auswertung (HD-Röntgen) nach FCI, Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Lagotto Romagnolo, Rottweiler, Chihuahua.