Necrotising myelopathy, IBA57-related(HNM)
Also known as: IBA57-related necrotizing myelopathy · Necrotizing myelopathy · IBA57 deficiency · IBA57-associated myelopathy · Nekrotisierende Myelopathie · …
Overview
What it is
This condition, also known as hereditary necrotizing myelopathy (HNM), is a severe, recessively inherited disorder affecting the spinal cord. A genetic defect in the IBA57 gene leads to the progressive degeneration and death, or necrosis, of nerve tissue in the central nervous system. This loss of nerve tissue disrupts the communication between the brain and the rest of the body.
How it presents
Symptoms typically appear in early puppyhood and include movement difficulties, weakness, and a loss of coordination in the limbs. These signs rapidly progress to complete paralysis.
Treatment
There is no cure for this progressive condition, and veterinary care is focused on diagnostic confirmation and compassionate end-of-life care. The associated costs for supportive care and euthanasia typically range from 300 to 1000 EUR.
How it's tested
IBA57-NM DNA-Test(IBA57-NM)
Primary testDNA testEin Gentest analysiert eine Blut- oder Speichelprobe auf die ursächliche Mutation im IBA57-Gen, um betroffene Hunde und Anlageträger sicher zu identifizieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Necrotising myelopathy, IBA57-related?
This condition, also known as hereditary necrotizing myelopathy (HNM), is a severe, recessively inherited disorder affecting the spinal cord. A genetic defect in the IBA57 gene leads to the progressive degeneration and death, or necrosis, of nerve tissue in the central nervous system. This loss of nerve tissue disrupts the communication between the brain and the rest of the body.
How is Necrotising myelopathy, IBA57-related tested?
Tests currently in our database: IBA57-NM DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.