Musladin-Lueke Syndrome(MLS)
Also known as: Musladin-Lueke-Syndrom · Chinese Beagle Syndrome · Beagle Hereditary Connective Tissue Disorder · MLS-Syndrom · Geleophysic dysplasia, ADMATSL2-related · …
Overview
What it is
Musladin-Lueke Syndrome (MLS) is an inherited connective tissue disorder that primarily affects Beagles. It is caused by a genetic mutation that leads to an abnormal buildup of collagen, which is the main structural protein in the body's supportive tissues. This buildup causes the skin, joints, and muscles to become abnormally stiff and hard.
How it presents
Owners typically notice symptoms in puppies between 2 and 4 weeks of age. Affected dogs develop a stiff, upright "toe-walking" gait, unusually tight or thick skin, and distinctively slanted, creased eyes.
Treatment
There is no cure for MLS, but the condition is manageable through lifelong supportive care, including physical therapy and pain management. Owners should expect ongoing veterinary and therapeutic costs ranging from 1,500 to 6,000 EUR over the dog's lifetime.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Musladin-Lueke Syndrom (MLS) DNA-Test(MLS)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im ADAMTSL2-Gen, die für das Musladin-Lueke-Syndrom (Geleophysic dysplasia) verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Musladin-Lueke Syndrome?
Musladin-Lueke Syndrome (MLS) is an inherited connective tissue disorder that primarily affects Beagles. It is caused by a genetic mutation that leads to an abnormal buildup of collagen, which is the main structural protein in the body's supportive tissues. This buildup causes the skin, joints, and muscles to become abnormally stiff and hard.
How is Musladin-Lueke Syndrome tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Musladin-Lueke Syndrom (MLS) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Beagle.