Muscular Dystrophy 2(MD)
Also known as: Muscular Dystrophy Type 2 · Limb-Girdle Muscular Dystrophy · LGMD · Sarcoglycanopathy · Gürtelmuskeldystrophie · …
Overview
What it is
Muscular Dystrophy 2 is an inherited genetic disorder that affects the skeletal muscles, specifically covering the subtypes LGMDR3 and LGMDR6. It is caused by a deficiency in essential structural proteins that normally protect muscle fibers from damage during movement. Without these proteins, the muscle cells gradually break down and degenerate over time.
How it presents
Owners typically notice symptoms in puppies or young adults, starting with a stiff, awkward gait and rapid fatigue during exercise. As the disease progresses, dogs develop visible muscle wasting and may experience difficulty swallowing.
Treatment
There is no cure for this progressive condition, so treatment focuses on lifelong supportive care to manage symptoms and maintain comfort. Managing this disease typically costs between €1,500 and €6,000 over the dog's lifetime.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Limb-Girdle Muscular Dystrophy Typ R3 (LGMDR3) Gentest(LGMDR3)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im SGCG-Gen, die zu einem Mangel an Gamma-Sarkoglykan führt, und ermöglicht den sicheren Nachweis von betroffenen Hunden sowie symptomfreien Anlageträgern.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Limb-Girdle-Muskeldystrophie Typ R6 (LGMDR6) DNA-Test(LGMDR6)
Primary testDNA testEin DNA-Test identifiziert die ursächliche Mutation im SGCD-Gen, die für die Gliedergürtel-Muskeldystrophie Typ R6 verantwortlich ist, und ermöglicht den Nachweis von Trägern und betroffenen Hunden.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Muscular Dystrophy 2?
Muscular Dystrophy 2 is an inherited genetic disorder that affects the skeletal muscles, specifically covering the subtypes LGMDR3 and LGMDR6. It is caused by a deficiency in essential structural proteins that normally protect muscle fibers from damage during movement. Without these proteins, the muscle cells gradually break down and degenerate over time.
How is Muscular Dystrophy 2 tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Limb-Girdle Muscular Dystrophy Typ R3 (LGMDR3) Gentest, Limb-Girdle-Muskeldystrophie Typ R6 (LGMDR6) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.