Muscular dystrophy, Ullrich type, COL6A3-related(UCMD)
Also known as: Ullrich congenital muscular dystrophy · Ullrich-type muscular dystrophy · COL6A3 muscular dystrophy · Collagen VI-deficient muscular dystrophy · Ullrich-Kongenitale Muskeldystrophie
Overview
What it is
This is an inherited muscle disorder caused by a genetic defect in collagen VI, which is a structural protein essential for holding muscle cells together. Without this properly functioning protein, the muscle tissue becomes unstable and progressively wastes away. This primarily damages the musculoskeletal system, leading to permanent muscle loss.
How it presents
Symptoms usually appear in puppies or young dogs. Owners will typically notice progressive muscle weakness, abnormal joint mobility, and increasing difficulty with basic movements like standing or walking.
Treatment
This condition is incurable, requiring lifelong palliative care, physiotherapy, and pain management to maintain quality of life. Managing this progressive disease involves ongoing veterinary care with expected lifetime costs ranging from 2,500 to 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Ullrich-Muskeldystrophie (UCMD) Gentest(UCMD)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im COL6A1-Gen, um betroffene Hunde sowie klinisch gesunde Träger der Ullrich-Muskeldystrophie nachzuweisen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Muscular dystrophy, Ullrich type, COL6A3-related?
This is an inherited muscle disorder caused by a genetic defect in collagen VI, which is a structural protein essential for holding muscle cells together. Without this properly functioning protein, the muscle tissue becomes unstable and progressively wastes away. This primarily damages the musculoskeletal system, leading to permanent muscle loss.
How is Muscular dystrophy, Ullrich type, COL6A3-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Ullrich-Muskeldystrophie (UCMD) Gentest, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.