Multiple System Degeneration (Chinese Crested)(CMSD)
Also known as: Canine Multiple System Degeneration · Cerebellar and Extrapyramidal Degeneration · Multiple System Degeneration in Chinese Crested Dogs · Progressive Neuronal Abiotrophy · PNA
Overview
What it is
Multiple System Degeneration, also known as Progressive Neuronal Abiotrophy (PNA), is an inherited neurological disease where specific areas of the brain, particularly the cerebellum, prematurely waste away. The cerebellum is the control center responsible for coordinating voluntary movements and balance. As these brain cells degenerate, the dog gradually loses the ability to control its motor functions.
How it presents
Symptoms typically begin between 3 and 6 months of age, starting with mild tremors, balance issues, and an unsteady gait. These coordination problems rapidly worsen over time, eventually making it impossible for the dog to stand or walk on its own.
Treatment
There is no cure for this progressive condition, and supportive care or diagnostic testing typically costs between 500 and 2000 EUR. Because the disease severely impacts quality of life, humane euthanasia is eventually necessary.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Multiple System Degeneration (Chinese Crested)?
Multiple System Degeneration, also known as Progressive Neuronal Abiotrophy (PNA), is an inherited neurological disease where specific areas of the brain, particularly the cerebellum, prematurely waste away. The cerebellum is the control center responsible for coordinating voluntary movements and balance. As these brain cells degenerate, the dog gradually loses the ability to control its motor functions.
How is Multiple System Degeneration (Chinese Crested) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.