Mucopolysaccharidosis IIIA(MPS IIIA)
Also known as: Mucopolysaccharidosis Type IIIA · Sanfilippo Syndrome A · Sanfilippo-Syndrom Typ A · MPS3A · Heparan Sulfate Sulfamidase Deficiency · …
Overview
What it is
Mucopolysaccharidosis IIIA is an inherited metabolic disorder where the body lacks a specific enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up to toxic levels inside cells, causing progressive and irreversible damage to the central nervous system, particularly the brain.
How it presents
Symptoms typically appear between 1 and 3 years of age, starting with mild coordination issues or tremors. Over time, owners will notice more severe signs such as personality changes, disorientation, and progressive difficulty moving.
Treatment
This condition is incurable, meaning treatment is lifelong and focused entirely on supportive care and pain management. Palliative veterinary care to keep the dog comfortable typically costs between 500 and 2000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Mucopolysaccharidosis IIIA?
Mucopolysaccharidosis IIIA is an inherited metabolic disorder where the body lacks a specific enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up to toxic levels inside cells, causing progressive and irreversible damage to the central nervous system, particularly the brain.
How is Mucopolysaccharidosis IIIA tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.