Modifier of copper toxicosis, RETN-related
Also known as: RETN-related copper toxicosis modifier · Resistin gene copper accumulation modifier · Copper toxicosis modifier RETN · RETN copper toxicosis risk factor · Resistin-associated copper toxicosis · …
Overview
What it is
This genetic variant in the RETN gene acts as a modifier for copper toxicosis, a metabolic condition affecting the liver. It does not cause the disease on its own, but it influences how severely copper accumulates in the liver tissue. This accumulation can lead to progressive liver damage and inflammation.
How it presents
Owners may notice signs of liver dysfunction, such as vomiting, lethargy, weight loss, or a yellowish tint to the skin and gums (jaundice). These symptoms typically become apparent in middle-aged dogs when the underlying copper storage disease is present.
Treatment
While the modifier itself is not treated, the underlying copper accumulation requires lifelong management with a low-copper diet and copper-chelating medications. Regular veterinary monitoring is necessary, with lifetime treatment costs typically ranging from 1,500 to 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Modifier of copper toxicosis, RETN-related?
This genetic variant in the RETN gene acts as a modifier for copper toxicosis, a metabolic condition affecting the liver. It does not cause the disease on its own, but it influences how severely copper accumulates in the liver tissue. This accumulation can lead to progressive liver damage and inflammation.
How is Modifier of copper toxicosis, RETN-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.