Modifier of copper toxicosis, ATP7A-related
Also known as: ATP7A copper toxicosis modifier · ATP7A-related copper accumulation · Copper toxicosis modifier ATP7A · X-linked copper accumulation modifier · Menkes gene disease modifier · …
Overview
What it is
This genetic variant in the ATP7A gene acts as a modifier for copper toxicosis, which is a metabolic disorder affecting the liver. It influences how copper is absorbed and stored in the body, potentially reducing the severity of copper accumulation in the liver. Because it is a modifier, it does not cause disease on its own but instead alters how another genetic condition behaves.
How it presents
On its own, this genetic modifier does not cause visible symptoms. Instead, it influences the onset and severity of liver-related signs associated with copper toxicosis, such as vomiting, lethargy, and yellowing of the skin or eyes (jaundice), which typically appear in middle-aged dogs.
Treatment
Management is focused on the primary copper toxicosis condition and involves lifelong therapy, including copper-chelating medications and a specialized low-copper diet. The lifetime cost of managing this metabolic condition typically ranges from 1,500 to 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Modifier of copper toxicosis, ATP7A-related?
This genetic variant in the ATP7A gene acts as a modifier for copper toxicosis, which is a metabolic disorder affecting the liver. It influences how copper is absorbed and stored in the body, potentially reducing the severity of copper accumulation in the liver. Because it is a modifier, it does not cause disease on its own but instead alters how another genetic condition behaves.
How is Modifier of copper toxicosis, ATP7A-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.