Cognitive enhancer metabolism
Also known as: Selegiline metabolism defect · Cognitive enhancer drug sensitivity · Altered metabolism of cognitive enhancers · Metabolizer of a cognitive enhancer · CYP1A2 mutation · …
Overview
What it is
This genetic condition involves a mutation in the CYP1A2 gene, which affects how the liver processes certain medications, specifically cognitive enhancers like selegiline. Because of this liver enzyme deficiency, affected dogs metabolize these specific drugs much slower than normal. This slower breakdown can lead to a buildup of the medication in the bloodstream, altering its effects.
How it presents
The genetic variant itself does not cause any visible symptoms or health limitations in daily life. Owners would only notice issues, such as signs of drug sensitivity or overdose, if the dog is prescribed specific cognitive medications in its senior years.
Treatment
No treatment is needed for the genetic variant itself, but veterinarians must adjust drug dosages or select alternative medications if cognitive therapy is required. Managing this condition is straightforward and carries a typical cost of 0 to 100 EUR for alternative prescriptions.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cognitive enhancer metabolism?
This genetic condition involves a mutation in the CYP1A2 gene, which affects how the liver processes certain medications, specifically cognitive enhancers like selegiline. Because of this liver enzyme deficiency, affected dogs metabolize these specific drugs much slower than normal. This slower breakdown can lead to a buildup of the medication in the bloodstream, altering its effects.
How is Cognitive enhancer metabolism tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.