Megakaryoblastic leukemia(AMKL)
Also known as: Acute megakaryoblastic leukemia · Megakaryozytäre Leukämie · Acute myeloid leukemia M7 · AML-M7 · Megakaryoblastenleukämie
Overview
What it is
Megakaryoblastic leukaemia is a rare, severe cancer of the bone marrow where abnormal, immature cells that normally produce blood platelets (megakaryoblasts) multiply uncontrollably. This rapid growth crowds out healthy blood cells, disrupting normal blood production. A definitive diagnosis requires specialized veterinary testing, specifically a bone marrow biopsy and immunophenotyping.
How it presents
This disease typically affects adult dogs, with symptoms appearing suddenly and progressing rapidly. Owners may notice extreme lethargy, a loss of appetite, fever, pale gums, and an increased tendency to bleed or bruise.
Treatment
The disease is rarely curable, and treatment is primarily palliative, focusing on chemotherapy and blood transfusions to temporarily extend and improve quality of life. Ongoing supportive care typically costs between 2,000 and 8,000 EUR.
How it's tested
Knochenmarkbiopsie und Immunphänotypisierung(Knochenmarkbiopsie)
Primary testClinical examDie Diagnose erfolgt über eine Knochenmarkbiopsie oder -aspiration mit anschließender zytologischer Untersuchung und Immunphänotypisierung (z. B. CD41/CD61-Marker) zur Identifikation von Megakaryoblasten.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Megakaryoblastic leukemia?
Megakaryoblastic leukaemia is a rare, severe cancer of the bone marrow where abnormal, immature cells that normally produce blood platelets (megakaryoblasts) multiply uncontrollably. This rapid growth crowds out healthy blood cells, disrupting normal blood production. A definitive diagnosis requires specialized veterinary testing, specifically a bone marrow biopsy and immunophenotyping.
How is Megakaryoblastic leukemia tested?
Tests currently in our database: Knochenmarkbiopsie und Immunphänotypisierung.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.