Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)(MCADD)
Also known as: Medium-chain acyl-CoA dehydrogenase deficiency · MCAD deficiency · Medium-Chain-Acyl-CoA-Dehydrogenase-Mangel · MCAD-Mangel · Canine MCADD · …
Overview
What it is
This is an inherited metabolic disorder where the body is unable to properly break down medium-chain fatty acids, which are specific types of fats used for energy. Because of a genetic variant in the ACADM gene, the metabolic system cannot convert these fats into fuel, leading to a severe energy deficit. This shortage of energy primarily impacts the liver and cellular function, especially during periods of fasting.
How it presents
Owners will typically notice symptoms during periods of fasting or stress, which include extreme lethargy, vomiting, weakness, and potentially severe seizures. These signs most commonly first appear in puppies or young dogs when they go too long without food.
Treatment
The condition is lifelong and cannot be cured, but it can be managed successfully by feeding a strict diet with frequent meals to avoid fasting. Emergency veterinary care may be needed for sudden crises, with overall management costs ranging from 1,000 to 5,000 EUR.
How it's tested
MCADD DNA-Test(MCADD)
Primary testDNA testEin DNA-Test identifiziert die Mutation im ACADM-Gen, die für den Mangel an mittelkettiger Acyl-CoA-Dehydrogenase verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)?
This is an inherited metabolic disorder where the body is unable to properly break down medium-chain fatty acids, which are specific types of fats used for energy. Because of a genetic variant in the ACADM gene, the metabolic system cannot convert these fats into fuel, leading to a severe energy deficit. This shortage of energy primarily impacts the liver and cellular function, especially during periods of fasting.
How is Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) tested?
Tests currently in our database: MCADD DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.