Marfan syndrome(MFS)
Also known as: Marfan-Syndrom · Canine Marfan Syndrome · FBN1 deficiency · Fibrillin-1 mutation
Overview
What it is
Marfan syndrome is a rare connective tissue disorder that weakens the body's structural support systems, particularly affecting the skeleton, eyes, and major blood vessels. In dogs, this condition is still poorly defined, and the exact genetic cause remains unknown, meaning no genetic test is currently available. The lack of proper tissue support leads to structural instability throughout the body.
How it presents
Symptoms typically become noticeable within the first year of life and include unusually long limbs, loose or unstable joints, and visible eye abnormalities such as a displaced lens. Owners may also notice weakness or exercise intolerance due to underlying heart defects.
Treatment
The condition is incurable and requires lifelong veterinary management, including regular heart monitoring and daily medications. Lifetime treatment and supportive care typically cost between €2,500 and €8,000.
How it's tested
Marfan-Syndrom DNA-Test(MFS)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im FBN1-Gen, die für das Marfan-Syndrom verantwortlich ist, und ermöglicht den frühzeitigen Nachweis betroffener Hunde.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Marfan syndrome?
Marfan syndrome is a rare connective tissue disorder that weakens the body's structural support systems, particularly affecting the skeleton, eyes, and major blood vessels. In dogs, this condition is still poorly defined, and the exact genetic cause remains unknown, meaning no genetic test is currently available. The lack of proper tissue support leads to structural instability throughout the body.
How is Marfan syndrome tested?
Tests currently in our database: Marfan-Syndrom DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.