Malignant Hyperthermia(MH)
Also known as: Canine Malignant Hyperthermia · Maligne Hyperthermie Syndrom · MHS · RYR1-related hyperthermia · Maligne Hyperthermie · …
Overview
What it is
Malignant hyperthermia, also known as Narkoseüberempfindlichkeit, is an inherited skeletal muscle disorder caused by a genetic mutation in the RYR1 gene. This mutation disrupts how calcium is regulated within the muscle cells, causing them to contract uncontrollably when triggered. These intense spasms generate a rapid, life-threatening rise in body temperature, typically brought on by specific anesthetic gases or extreme physical stress.
How it presents
Symptoms can emerge at any age, most commonly during general anesthesia or periods of intense physical exertion. An owner or veterinarian will notice sudden muscle stiffness, a racing heartbeat, rapid breathing, and a dangerously high fever.
Treatment
An acute crisis is a severe medical emergency requiring immediate intensive care, with treatment costs typically ranging from 1,000 to 4,000 EUR. While the underlying genetic condition is lifelong, it is managed preventatively by avoiding known trigger anesthetics and minimizing extreme stress.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Maligne Hyperthermie DNA-Test(MH)
Primary testDNA testDer DNA-Test auf Maligne Hyperthermie identifiziert eine Mutation im RYR1-Gen, die bei betroffenen Hunden unter Inhalationsnarkose zu lebensbedrohlichen Stoffwechselentgleisungen führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Malignant Hyperthermia?
Malignant hyperthermia, also known as Narkoseüberempfindlichkeit, is an inherited skeletal muscle disorder caused by a genetic mutation in the RYR1 gene. This mutation disrupts how calcium is regulated within the muscle cells, causing them to contract uncontrollably when triggered. These intense spasms generate a rapid, life-threatening rise in body temperature, typically brought on by specific anesthetic gases or extreme physical stress.
How is Malignant Hyperthermia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Maligne Hyperthermie DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Brazilian Terrier, Canadian Shepherd, Chart Polski, Greyhound, Spanish Galgo, Gascon Saintongeois, Montenegrin Mountain Hound.