Cleft lip with or without cleft palate, ADAMTS20-related(CLP)
Also known as: Cleft lip with or without cleft palate · CL/P · ADAMTS20-related cleft lip and palate · Spaltlippe und Gaumenspalte · Lippen-Kiefer-Gaumenspalte
Overview
What it is
This is a congenital developmental defect of the skull and mouth, specifically associated with a genetic mutation in the ADAMTS20 gene in Nova Scotia Duck Tolling Retrievers. During embryonic development, the tissues forming the upper lip and the roof of the mouth, known as the palate, fail to fuse completely, resulting in a physical gap. Affected puppies may also exhibit syndactyly, which is the abnormal fusion of the toes.
How it presents
The condition is visible immediately at birth as a noticeable split in the upper lip, the roof of the mouth, or both. Affected puppies typically struggle to nurse, choke frequently, and may have milk draining from their nostrils.
Treatment
Treatment requires complex surgical reconstruction of the lip and palate during puppyhood, alongside intensive hand-feeding and supportive care. While these surgeries can correct the physical defects, they are highly specialized and typically cost between €1,500 and €6,000.
How it's tested
ADAMTS20 DNA-Test (Cleft Lip/Palate)(CLP)
Primary testDNA testEin DNA-Test identifiziert die Mutation im ADAMTS20-Gen, die für die Lippen-Kiefer-Gaumenspalte verantwortlich ist, und ermöglicht den Nachweis von Anlageträgern.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cleft lip with or without cleft palate, ADAMTS20-related?
This is a congenital developmental defect of the skull and mouth, specifically associated with a genetic mutation in the ADAMTS20 gene in Nova Scotia Duck Tolling Retrievers. During embryonic development, the tissues forming the upper lip and the roof of the mouth, known as the palate, fail to fuse completely, resulting in a physical gap. Affected puppies may also exhibit syndactyly, which is the abnormal fusion of the toes.
How is Cleft lip with or without cleft palate, ADAMTS20-related tested?
Tests currently in our database: ADAMTS20 DNA-Test (Cleft Lip/Palate).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.