Lipid malabsorption, ACSL5-related(ILM)
Also known as: ACSL5 lipid malabsorption · Congenital lipid malabsorption · Fat malabsorption ACSL5-related · Intestinal lipid malabsorption · ACSL5-assoziierte Lipidmalabsorption
Overview
What it is
This is an inherited metabolic disorder of the digestive system, primarily affecting the Australian Kelpie breed, where the intestines cannot properly absorb or process dietary fats. It is caused by a specific genetic deletion involving the ACSL5 gene, which is essential for fat metabolism. Without this functioning gene, the body cannot utilize fats from food, leading to severe nutritional deficiencies.
How it presents
Symptoms typically become noticeable in puppies shortly after weaning. Owners will usually observe chronic, fatty diarrhea, a dull coat, and a failure to gain weight despite the puppy having a ravenous appetite.
Treatment
The condition is incurable and requires lifelong management with a strict, specialized low-fat diet and nutritional support. Lifetime management costs, including dietary adjustments and veterinary check-ups, typically range from 2,000 to 7,000 EUR.
How it's tested
ACSL5-Lipid-Malabsorption DNA-Test(ACSL5)
Primary testDNA testEin Gentest, der die Mutation im ACSL5-Gen identifiziert, um Hunde zu erkennen, die von Lipid-Malabsorption betroffen oder Träger sind.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Lipid malabsorption, ACSL5-related?
This is an inherited metabolic disorder of the digestive system, primarily affecting the Australian Kelpie breed, where the intestines cannot properly absorb or process dietary fats. It is caused by a specific genetic deletion involving the ACSL5 gene, which is essential for fat metabolism. Without this functioning gene, the body cannot utilize fats from food, leading to severe nutritional deficiencies.
How is Lipid malabsorption, ACSL5-related tested?
Tests currently in our database: ACSL5-Lipid-Malabsorption DNA-Test.
Which breeds are most affected?
Most commonly affected: Australian Kelpie.