Limb movement, synchronic, EFNB3-related
Also known as: Synchronous hind limb movement · EFNB3-related bunny hopping · Bunny-hopping gait · EFNB3-associated synchronous gait · Synchrone Gliedmaßenbewegung
Overview
What it is
This is a severe neurodevelopmental disorder of the nervous system caused by a genetic mutation in the EFNB3 gene. The mutation prevents the normal crossing of nerve pathways in the spinal cord, which normally allows the left and right sides of the body to coordinate independently. Instead, signals are sent to the limbs in parallel, causing them to move at the same time rather than alternately.
How it presents
Affected Weimaraner puppies show severe coordination issues from early puppyhood, most notably a synchronized, rabbit-like hopping gait. The neurological impairment is highly severe and prevents normal development.
Treatment
There is no treatment or cure for this condition, and it unfortunately leads to early euthanasia. Expected costs range from 100 to 500 EUR, which covers basic veterinary diagnostics and humane end-of-life care.
How it's tested
EFNB3 DNA-Test (Synchrone Gliedmaßenbewegung)(EFNB3)
Primary testDNA testEin DNA-Test, der die ursächliche Mutation im EFNB3-Gen identifiziert, um betroffene Hunde, Träger und mutationsfreie Tiere zu bestimmen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Limb movement, synchronic, EFNB3-related?
This is a severe neurodevelopmental disorder of the nervous system caused by a genetic mutation in the EFNB3 gene. The mutation prevents the normal crossing of nerve pathways in the spinal cord, which normally allows the left and right sides of the body to coordinate independently. Instead, signals are sent to the limbs in parallel, causing them to move at the same time rather than alternately.
How is Limb movement, synchronic, EFNB3-related tested?
Tests currently in our database: EFNB3 DNA-Test (Synchrone Gliedmaßenbewegung).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.