Leukocyte adhesion deficiency, type III(LAD III)
Also known as: Leukocyte Adhesion Deficiency Type III · LAD3 · Canine LAD III · FERMT3 deficiency · Leukozytenadhäsionsdefekt Typ III · …
Overview
What it is
Leukocyte Adhesion Deficiency Type III (LAD III) is an inherited disorder affecting both white blood cells and platelets, which are crucial components of the immune and blood-clotting systems. In affected dogs, a genetic defect prevents these cells from sticking to blood vessel walls, meaning white blood cells cannot reach infections and platelets cannot form clots. This dual defect leads to both severe, recurrent infections and a dangerous inability to stop bleeding.
How it presents
Symptoms typically appear within the first few weeks of a puppy's life. Owners will notice slow-healing wounds, gum inflammation, recurrent infections, and severe, prolonged bleeding from minor cuts or during teething.
Treatment
There is no cure for this condition, and it is unfortunately fatal at a young age. Supportive care, including intensive antibiotics and transfusions, can help manage symptoms temporarily and typically costs between 2,000 and 7,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Leukocyte adhesion deficiency, type III?
Leukocyte Adhesion Deficiency Type III (LAD III) is an inherited disorder affecting both white blood cells and platelets, which are crucial components of the immune and blood-clotting systems. In affected dogs, a genetic defect prevents these cells from sticking to blood vessel walls, meaning white blood cells cannot reach infections and platelets cannot form clots. This dual defect leads to both severe, recurrent infections and a dangerous inability to stop bleeding.
How is Leukocyte adhesion deficiency, type III tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.