Leukocyte Adhesion Deficiency Type I (Irish Setter)(CLAD-I)
Also known as: Canine Leukocyte Adhesion Deficiency · CLAD · Leukocyte Adhesion Deficiency Type I · Canine Granulocytopathy · Granulozyten-Adhäsionsdefizienz · …
Overview
What it is
Leukocyte Adhesion Deficiency Type I is a severe inherited immune system disorder where white blood cells cannot properly stick to and migrate into infected tissues. Because these defensive cells cannot reach the site of an infection, the body is unable to fight off bacteria and other pathogens. This leads to widespread, uncontrolled infections throughout the body.
How it presents
Symptoms typically appear in young puppies and include recurrent, slow-healing infections of the skin, gums, and respiratory tract, often accompanied by a persistent fever. Owners may also notice severe swelling of the gums and lymph nodes.
Treatment
There is no cure for this condition, and it is unfortunately fatal at a young age. Supportive care with antibiotics can temporarily manage infections, with treatment costs typically ranging from 1,000 to 5,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Leukocyte Adhesion Deficiency Type I (Irish Setter)?
Leukocyte Adhesion Deficiency Type I is a severe inherited immune system disorder where white blood cells cannot properly stick to and migrate into infected tissues. Because these defensive cells cannot reach the site of an infection, the body is unable to fight off bacteria and other pathogens. This leads to widespread, uncontrolled infections throughout the body.
How is Leukocyte Adhesion Deficiency Type I (Irish Setter) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: English Pointer, English Setter, Irish Red and White Setter, Irish Red Setter.