Lethal Acrodermatitis(LAD)
Also known as: Lethale Akrodermatitis · Zinc-unresponsive acrodermatitis · Bull Terrier lethal acrodermatitis · Acrodermatitis lethalis · Acrodermatitis enteropathica-like syndrome · …
Overview
What it is
Lethal acrodermatitis is an inherited metabolic disorder that affects a dog's skin and immune system. It is caused by an inability to properly process zinc, which leads to severe skin inflammation and a weakened ability to fight off infections.
How it presents
Symptoms typically appear in early puppyhood. Owners will notice painful, crusted, and cracked paw pads, skin lesions around the face, slowed growth, and frequent infections.
Treatment
There is no cure for this condition, and it does not respond to zinc supplementation. Supportive care to manage symptoms and infections typically costs between 500 and 3000 EUR, but due to the severe impact on quality of life, affected dogs are usually euthanized at a young age.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Lethal Acrodermatitis (LAD) DNA-Test(LAD)
Primary testDNA testEin molekularbiologischer Gentest, der die ursächliche Mutation im MKLN1-Gen identifiziert, um betroffene Hunde (Anlageträger oder Merkmalsträger) für Letale Akrodermatitis nachzuweisen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Lethal Acrodermatitis?
Lethal acrodermatitis is an inherited metabolic disorder that affects a dog's skin and immune system. It is caused by an inability to properly process zinc, which leads to severe skin inflammation and a weakened ability to fight off infections.
How is Lethal Acrodermatitis tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Lethal Acrodermatitis (LAD) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Bull Terrier, Miniature Bull Terrier.