Laryngeal paralysis and polyneuropathy, CNTNAP1-related(LPPN3)
Also known as: Laryngeal Paralysis and Polyneuropathy Type 3 · CNTNAP1-associated polyneuropathy · Leonberger Polyneuropathy 3 · CNTNAP1-related LPPN · Kehlkopflähmung und Polyneuropathie Typ 3 · …
Overview
What it is
This is an inherited neurological disorder caused by a genetic mutation affecting the peripheral nervous system, which controls the muscles and limbs. It leads to progressive laryngeal paralysis, meaning the vocal cords and airway cannot open properly, alongside widespread nerve damage. This combination severely impairs both the dog's ability to breathe and their coordination.
How it presents
Symptoms typically appear within the first few months of life. Owners will notice noisy or labored breathing, changes in the dog's bark, difficulty swallowing, and a progressive weakness or wobbliness in the legs.
Treatment
There is no cure for this progressive condition, and management focuses on supportive care or diagnostic confirmation, which typically costs between €1,000 and €4,000. Because the disease worsens rapidly and severely impacts quality of life, humane euthanasia is often considered.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Laryngeal paralysis and polyneuropathy, CNTNAP1-related?
This is an inherited neurological disorder caused by a genetic mutation affecting the peripheral nervous system, which controls the muscles and limbs. It leads to progressive laryngeal paralysis, meaning the vocal cords and airway cannot open properly, alongside widespread nerve damage. This combination severely impairs both the dog's ability to breathe and their coordination.
How is Laryngeal paralysis and polyneuropathy, CNTNAP1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Leonberger.