Lafora disease(Lafora)
Also known as: Lafora-Krankheit · Myoklonusepilepsie vom Typ Lafora · Progressive Myoclonus Epilepsy · EPM2B · Lafora's disease · …
Overview
What it is
Lafora disease is an inherited brain disorder caused by an abnormal buildup of starch-like compounds inside the nerve cells. This accumulation gradually damages the central nervous system, preventing the brain from functioning normally. Over time, this leads to progressive neurological decline and recurrent seizures.
How it presents
Symptoms typically begin around 5 years of age, often starting with sudden muscle twitches or jerks triggered by flashing lights, sudden sounds, or movement. Owners may also notice generalized seizures, progressive vision loss, and signs of dementia, which worsen over time.
Treatment
There is no cure for this progressive condition, but symptoms can be managed using lifelong anti-epileptic medications and dietary adjustments. Managing this disease requires ongoing veterinary care, with lifetime costs typically ranging from €2,000 to €7,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Lafora disease?
Lafora disease is an inherited brain disorder caused by an abnormal buildup of starch-like compounds inside the nerve cells. This accumulation gradually damages the central nervous system, preventing the brain from functioning normally. Over time, this leads to progressive neurological decline and recurrent seizures.
How is Lafora disease tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Basset Hound, Beagle, Miniature Wire-haired Dachshund.