L-2-Hydroxyglutaric Aciduria (Staffordshire Bull Terrier)(L-2-HGA)
Also known as: L-2-hydroxyglutaric aciduria · L-2-hydroxyglutaric acidemia · L2HGA · L-2-Hydroxyglutarsäureurie · L-2-Hydroxyglutarsäure-Azidämie
Overview
What it is
L-2-Hydroxyglutaric aciduria (L-2-HGA) is an inherited metabolic disorder that affects the central nervous system. Due to a missing or defective enzyme, a metabolic byproduct called L-2-hydroxyglutaric acid builds up to toxic levels in the brain and spinal cord. This accumulation causes progressive damage to these vital nerve tissues over time.
How it presents
Symptoms usually begin to appear between 6 and 12 months of age. Owners may notice muscle stiffness, a wobbly or uncoordinated gait, behavioral changes, and epileptic seizures.
Treatment
There is no cure for this condition, meaning treatment is lifelong and focuses on managing symptoms like seizures with medication. Managing this disease over a dog's lifetime typically costs between 2,000 and 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
L-2-Hydroxyglutarazidämie (L-2-HGA) DNA-Test(L-2-HGA)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der kausalen Mutation im L2HGDH-Gen, die für die L-2-Hydroxyglutarazidämie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is L-2-Hydroxyglutaric Aciduria (Staffordshire Bull Terrier)?
L-2-Hydroxyglutaric aciduria (L-2-HGA) is an inherited metabolic disorder that affects the central nervous system. Due to a missing or defective enzyme, a metabolic byproduct called L-2-hydroxyglutaric acid builds up to toxic levels in the brain and spinal cord. This accumulation causes progressive damage to these vital nerve tissues over time.
How is L-2-Hydroxyglutaric Aciduria (Staffordshire Bull Terrier) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), L-2-Hydroxyglutarazidämie (L-2-HGA) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Staffordshire Bull Terrier.