Congenital Myasthenic Syndrome(CMS)
Also known as: Kongenitale Myasthenie · Hereditary Myasthenia · Neuromuskuläre Synapsenschwäche · Erblich bedingte Muskelschwäche · COLQ-CMS · …
Overview
What it is
Congenital Myasthenic Syndrome (CMS) is an inherited genetic disorder that disrupts the communication between nerves and muscles. This breakdown in the neuromuscular system prevents signals from reaching the muscles properly, leading to rapid muscle fatigue and weakness. Unlike some other muscle-weakness disorders, this is a congenital condition present from birth and is not caused by an autoimmune system malfunction.
How it presents
Symptoms typically appear in puppies between 3 and 12 weeks of age, starting with extreme weakness or collapse after brief exercise. Owners will often notice a stiff, wobbly gait, though the puppy usually recovers temporarily after a short period of rest.
Treatment
While CMS is a lifelong, incurable condition, symptoms can often be managed with daily medication to support nerve-to-muscle signaling. Ongoing veterinary care and lifelong treatment typically cost between 1,500 and 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Acetylcholinrezeptor-Antikörper-Test(AChR-Ab)
Primary testClinical examDer Nachweis von Autoantikörpern gegen Acetylcholinrezeptoren (AChR) im Blutserum gilt als Goldstandard zur Diagnose der erworbenen Myasthenia gravis beim Hund.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Kongenitales Myasthenisches Syndrom (CMS) DNA-Test(CMS)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation für das Kongenitale Myasthenische Syndrom (CMS), eine erbliche Störung der neuromuskulären Übertragung.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Congenital Myasthenic Syndrome?
Congenital Myasthenic Syndrome (CMS) is an inherited genetic disorder that disrupts the communication between nerves and muscles. This breakdown in the neuromuscular system prevents signals from reaching the muscles properly, leading to rapid muscle fatigue and weakness. Unlike some other muscle-weakness disorders, this is a congenital condition present from birth and is not caused by an autoimmune system malfunction.
How is Congenital Myasthenic Syndrome tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Acetylcholinrezeptor-Antikörper-Test, Kongenitales Myasthenisches Syndrom (CMS) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: English Springer Spaniel, Parson Russell Terrier, German Shepherd.